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    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.

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